cdk6 cell signaling Search Results


cdk6 3136 cell signaling mouse  (Cell Signaling Technology Inc)
96
Cell Signaling Technology Inc cdk6 3136 cell signaling mouse
Cdk6 3136 Cell Signaling Mouse, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/cdk6 3136 cell signaling mouse/product/Cell Signaling Technology Inc
Average 96 stars, based on 1 article reviews
cdk6 3136 cell signaling mouse - by Bioz Stars, 2026-03
96/100 stars
  Buy from Supplier
cdk6  (Cell Signaling Technology Inc)
96
Cell Signaling Technology Inc cdk6
A) The fitness effects of CRISPR-Cas9 gene knockout on TP53 , CDK4 , <t>CDK6</t> , and RB1 genes (DepMap Public+Score, Chronos, https://depmap.org/portal/ )) were correlated with trilaciclib sensitivity across 694 cell lines. Pearson correlation coefficient (r) and p-value are shown in each graph. B-C) The sensitivity of trilaciclib varies across different histologic cancer types (DepMap, BRD: BRD-K00003412-300-01-9, PRISM Repurposing Public 23Q2; https://depmap.org/portal/ ). In C) blood cancers are subdivided into Hodgkin lymphoma (HL, 2 cell lines), acute myeloid leukaemia (AML, 21 cell lines), T-cell acute lymphoblastic leukaemia/ lymphoma (T-ALL/LBL, 10 cell lines), myeloproliferative neoplasms (MPN, 12 cell lines), non-Hodgkin lymphoma (NHL, 54 cell lines), and B-cell acute lymphoblastic leukaemia/ lymphoma (B-ALL/LBL, 9 cell lines). D) The inhibition concentration at 50 % cell death (IC50) curves were analysed in K562, JURKAT, U937, MOLT-4, and NCI-H929 cells after 72 hours of treatment. Standard deviation of four biological replicates is shown. E) Percentage of live cells (Annexin V negative and 7-AAD negative cells, light blue), apoptotic cells (Annexin V positive and 7-AAD negative cells, purple), and necrotic cells (7-AAD positive cells, pink) after 72 hours of treatment. The statistical significance of the comparisons with resting is indicated as follows: ‡, P ≤ 0.001; ns, not significant. Standard deviation of three biological replicates is shown.
Cdk6, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/cdk6/product/Cell Signaling Technology Inc
Average 96 stars, based on 1 article reviews
cdk6 - by Bioz Stars, 2026-03
96/100 stars
  Buy from Supplier

Image Search Results


A) The fitness effects of CRISPR-Cas9 gene knockout on TP53 , CDK4 , CDK6 , and RB1 genes (DepMap Public+Score, Chronos, https://depmap.org/portal/ )) were correlated with trilaciclib sensitivity across 694 cell lines. Pearson correlation coefficient (r) and p-value are shown in each graph. B-C) The sensitivity of trilaciclib varies across different histologic cancer types (DepMap, BRD: BRD-K00003412-300-01-9, PRISM Repurposing Public 23Q2; https://depmap.org/portal/ ). In C) blood cancers are subdivided into Hodgkin lymphoma (HL, 2 cell lines), acute myeloid leukaemia (AML, 21 cell lines), T-cell acute lymphoblastic leukaemia/ lymphoma (T-ALL/LBL, 10 cell lines), myeloproliferative neoplasms (MPN, 12 cell lines), non-Hodgkin lymphoma (NHL, 54 cell lines), and B-cell acute lymphoblastic leukaemia/ lymphoma (B-ALL/LBL, 9 cell lines). D) The inhibition concentration at 50 % cell death (IC50) curves were analysed in K562, JURKAT, U937, MOLT-4, and NCI-H929 cells after 72 hours of treatment. Standard deviation of four biological replicates is shown. E) Percentage of live cells (Annexin V negative and 7-AAD negative cells, light blue), apoptotic cells (Annexin V positive and 7-AAD negative cells, purple), and necrotic cells (7-AAD positive cells, pink) after 72 hours of treatment. The statistical significance of the comparisons with resting is indicated as follows: ‡, P ≤ 0.001; ns, not significant. Standard deviation of three biological replicates is shown.

Journal: bioRxiv

Article Title: Proteomic Analysis Reveals Trilaciclib-Induced Senescence

doi: 10.1101/2024.03.12.584620

Figure Lengend Snippet: A) The fitness effects of CRISPR-Cas9 gene knockout on TP53 , CDK4 , CDK6 , and RB1 genes (DepMap Public+Score, Chronos, https://depmap.org/portal/ )) were correlated with trilaciclib sensitivity across 694 cell lines. Pearson correlation coefficient (r) and p-value are shown in each graph. B-C) The sensitivity of trilaciclib varies across different histologic cancer types (DepMap, BRD: BRD-K00003412-300-01-9, PRISM Repurposing Public 23Q2; https://depmap.org/portal/ ). In C) blood cancers are subdivided into Hodgkin lymphoma (HL, 2 cell lines), acute myeloid leukaemia (AML, 21 cell lines), T-cell acute lymphoblastic leukaemia/ lymphoma (T-ALL/LBL, 10 cell lines), myeloproliferative neoplasms (MPN, 12 cell lines), non-Hodgkin lymphoma (NHL, 54 cell lines), and B-cell acute lymphoblastic leukaemia/ lymphoma (B-ALL/LBL, 9 cell lines). D) The inhibition concentration at 50 % cell death (IC50) curves were analysed in K562, JURKAT, U937, MOLT-4, and NCI-H929 cells after 72 hours of treatment. Standard deviation of four biological replicates is shown. E) Percentage of live cells (Annexin V negative and 7-AAD negative cells, light blue), apoptotic cells (Annexin V positive and 7-AAD negative cells, purple), and necrotic cells (7-AAD positive cells, pink) after 72 hours of treatment. The statistical significance of the comparisons with resting is indicated as follows: ‡, P ≤ 0.001; ns, not significant. Standard deviation of three biological replicates is shown.

Article Snippet: Then, it was probed with phospho-Rb (Ser 807/811) (#8516, Cell Signaling), p21 (#2947, Cell Signaling), CDK4 (sc-23896, Santa Cruz), CDK6 (#13331, Cell Signaling), α-Tubulin (T9026) (Sigma-Aldrich) antibodies overnight at 4 °C.

Techniques: CRISPR, Gene Knockout, Inhibition, Concentration Assay, Standard Deviation